Publications

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Journal Articles

78
Huang, E. Y.-W.; Kuang, F.; Wu, H.; Yu, C. X.; Chen, X.; Vasku, G.; Nguyen, L. T. A.; Jeppe, K. J.; Coussens, A. K.; Kwai, B. X. C.; Leung, I. K. H. An Integrated Structural and Biophysical Approach to Study Carbon Metabolism in Mycobacterium tuberculosis. QRB Discov. 2025, Accepted Manuscript. DOI: 10.1017/qrd.2025.6

77
Lyu, B.; Manna, B.; Zhou, X.; Leung, I. K. H.; Singhal, N. Microbial Metabolic Enzymes, Pathways and Microbial Hosts for Co-Metabolic Degradation of Organic Micropollutants in Wastewater. Water Res. 2025, 276, 123229. DOI: 10.1016/j.watres.2025.123229

76
Nuske, M. R.; Zhong, J.; Huang, R.; Sarojini, V.; Chen, J. L. Y.; Squire, C. J.; Blaskovich, M. A. T.; Leung, I. K. H. Adjuvant Strategies to Tackle Mcr-Mediated Polymyxin Resistance. RSC Med. Chem. 2025, 16, 465–480. DOI: 10.1039/D4MD00654B

75
Harris, B. A.; Zhou, J.; Clarke, B. O.; Leung, I. K. H. Enzymatic Degradation of PFAS: Current Status and Ongoing Challenges. ChemSusChem 2025, 18, e202401122. DOI: 10.1002/cssc.202401122

74
Ghosh, S.; Melton, L. D.; Kihara, S.; Huang, R.; Leung, I. K. H.; Rekas, A.; Knott, R.; Seal, C.; Nieuwoudt, M.; McGillivray, D. J. Probing the Binding Sites of Bioactives with β-Lactoglobulin at Different Gastrointestinal pHs. Food Hydrocoll. 2024, 153, 110040. DOI: 10.1016/j.foodhyd.2024.110040

73
Eurtivong, C.; Leung, E.; Sharma, N.; Leung, I. K. H.; Reynisson, J. Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target. Molecules 2023, 28, 5637. DOI: 10.3390/molecules28155637

72
Huang, E. Y.-W.; Kwai, B. X. C.; Bhusal, R. P.; Bashiri, G.; Leung, I. K. H. Mycobacterium tuberculosis Rv1916 is an Acetyl-CoA-Binding Protein. ChemBioChem 2023, 24, e202300162. DOI: 10.1002/cbic.202300162

71
Zhang, S.; De Leon Rodriguez, L. M.; Li, F. F.; Huang, R.; Leung, I. K. H.; Harris, P.; Brimble. M. A. A Novel Tyrosine Hyperoxidation Enables Selective Peptide Cleavage. Chem. Sci. 2022, 13, 2753–2763. DOI: 10.1039/D1SC06216F

70
Shishodia, S.; Demetriades, M.; Zhang, D.; Tam, N. Y.; Maheswaran, P.; Clunie-O’Connor, C.; Tumber, A.; Leung, I. K. H.; Ng, Y. M.; Leissing, T. M.; El-Sagheer, A. H.; Salah, E.; Brown, T.; Aik, W. S.; McDonough, M. A.; Schofield, C. J. Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J. Med. Chem. 2021, 64, 16609–16625. DOI: 10.1021/acs.jmedchem.1c01204

69
Sharma, N.; Leung, I. K. H. Novel Thermophilic Bacterial Laccase for the Degradation of Aromatic Organic Pollutants. Front. Chem. 2021, 9, 711345. DOI: 10.3389/fchem.2021.711345

68
Sharma, N.; Leung, I. K. H. Characterisation and Optimisation of a Novel Laccase from Sulfitobacter indolifex for the Decolourisation of Organic Dyes. Int. J. Biol. Macromol. 2021, 190, 574–584. DOI: 10.1016/j.ijbiomac.2021.09.003

67
Leung, E.; Patel, J.; Hollywood, J. A.; Zafar, A.; Tomek, P.; Barker, D.; Pilkington, L. I.; van Rensburg, M.; Langley, R. J.; Helsby, N. A.; Squire, C. J.; Baguley, B. C.; Denny, W. A.; Reynisson, J.; Leung, I. K. H. Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncol. Ther. 2021, 9, 541–556. DOI: 10.1007/s40487-021-00158-0

66
Mbenza, N. M.; Nasarudin, N.; Vadakkedath, P. G.; Patel, K.; Ismail, A. Z.; Hanif, M.; Wright, L. J.; Sarojini, V.; Hartinger, C. G.; Leung, I. K. H. Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2. ChemBioChem 2021, 22, 2521–2525. DOI: 10.1002/cbic.202100181

65
Mak, O. W.; Sharma, N.; Reynisson, J.; Leung, I. K. H. Discovery of Novel Hsp90 C-Terminal Domain Inhibitors that Disrupt Co-Chaperone Binding. Bioorg. Med. Chem. Lett. 2021, 38, 127857. DOI: 10.1016/j.bmcl.2021.127857

64
Sharma, N.; Langley, R. J.; Eurtivong, C.; Leung, E.; Dixon, R. J.; Paulin, E. K.; Rees, S. W. P.; Pilkington, L. I.; Barker, D.; Reynisson, J.; Leung, I. K. H. An Optimised MALDI-TOF Assay for Phosphatidylcholine-Specific Phospholipase C. Anal. Methods 2021, 13, 491–496. DOI: 10.1039/D0AY02208J

63
Kwai, B. X. C.; Collins, A. J.; Middleditch, M. J.; Sperry, J.; Bashiri, G.; Leung, I. K. H. Itaconate is a Covalent Inhibitor of the Mycobacterium tuberculosis Isocitrate Lyase. RSC Med. Chem. 2021, 12, 57–61. DOI: 10.1039/D0MD00301H

62
Correddu, D.; Sharma, N.; Kaur, S.; Varnava, K. G.; Mbenza, N. M.; Sarojini, V.; Leung, I. K. H. An Investigation into the Effect of Ribosomal Protein S15 Phosphorylation to its Intermolecular Interactions by Using Phosphomimetic Mutant. Chem. Commun. 2020, 56, 7857–7860. DOI: 10.1039/D0CC01618G

61
McLarin, M.-A.; Leung, I. K. H. Substrate Specificity of Polyphenol Oxidase. Crit. Rev. Biochem. Mol. Biol. 2020, 55, 274–308. DOI: 10.1080/10409238.2020.1768209

60
Pilkington, L. I.; Sparrow, K.; Rees, S. W. P.; Paulin, E. K.; van Rensburg, M.; Xu, C. S.; Langley, R. J.; Leung, I. K. H.; Reynisson, J.; Leung, E.; Barker, D. Development, Synthesis and Biological Investigation of a Novel Class of Potent PC-PLC Inhibitors. Eur. J. Med. Chem. 2020, 191, 112162. DOI: 10.1016/j.ejmech.2020.112162

59
Mohan, A.; Hadi, J.; Gutierrez-Maddox, N.; Li, Y.; Leung, I. K. H.; Gao, Y.; Shu, Q.; Quek, S.-Y. Sensory, Microbiological and Physicochemical Characterisation of Functional Manuka Honey Yogurts Containing Probiotic Lactobacillus reuteri DPC16. Foods 2020, 9, 106. DOI: 10.3390/foods9010106

58
Eurtivong, C.; Pilkington, L. I.; van Rensburg, M.; White, R. M.; Brar, H. K.; Rees, S.; Paulin, E. K.; Xu, C. S.; Sharma, N.; Leung, I. K. H.; Leung, E.; Barker, D.; Reynisson, J. Discovery of Novel Phosphatidylcholine-Specific Phospholipase C Drug-like Inhibitors as Potential Anticancer Agents. Eur. J. Med. Chem. 2020, 187, 111919. DOI: 10.1016/j.ejmech.2019.111919

57
Correddu, D.; Montaño López, J. d. J.; Angermayr, S. A.; Middleditch, M. J.; Payne, L. S.; Leung, I. K. H. Effect of Consecutive Rare Codons on the Recombinant Production of Human Proteins in Escherichia coli. IUBMB Life 2020, 72, 266–274. DOI: 10.1002/iub.2162

56
Khomenko, T. M.; Zakharenko, A. L.; Chepanova, A. A.; Ilina, E. S.; Zakharova, O. D.; Kaledin, V. I.; Nikolin, V. P.; Popova, N. A.; Korchagina, D. V.; Reynisson, J.; Chand, R.; Ayine-Tora, D. M.; Patel, J.; Leung, I. K. H.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy. Int. J. Mol. Sci. 2020, 21, 126. DOI: 10.3390/ijms21010126

55
Mak, O. W.; Chand, R.; Reynisson, J.; Leung, I. K. H. Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90). Int. J. Mol. Sci. 2020, 20, 5333. DOI: 10.3390/ijms20215333

54
Filimonov, A. S.; Chepanova, A. A.; Luzina, O. A.; Zakharenko, A. L.; Zakharova, O. D.; Ilina, E. S.; Dyrkheeva, N. S.; Kuprushkin, M. S.; Kolotaev, A. V.; Khachatryan, D. S.; Patel, J.; Leung, I. K. H.; Chand, R.; Ayine‐Tora, D. M.; Reynisson, J.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. Molecules 2019, 24, 3711. DOI: 10.3390/molecules24203711

53
Bhusal, R. P.; Jiao, W.; Kwai, B. X. C.; Reynisson, J.; Collins, A. J.; Sperry, J.; Bashiri, G.; Leung, I. K. H. Acetyl-CoA-Mediated Activation of Mycobacterium tuberculosis Isocitrate Lyase 2. Nat. Commun. 2019, 10, 4639. DOI: 10.1038/s41467-019-12614-7

52
Li, Y.; McLarin, M.-A.; Middleditch, M. J.; Morrow, S. J.; Kilmartin, P. A.; Leung, I. K. H. An Approach to Recombinantly Produce Mature Grape Polyphenol Oxidase. Biochimie 2019, 165, 40–47. DOI: 10.1016/j.biochi.2019.07.002

51
Chepanova, A. A.; Mozhaitsev, E. S.; Munkuev, A. A.; Suslov, E. V.; Korchagina, D. V.; Zakharova, O. D.; Zakharenko, A. L.; Patel, J.; Ayine-Tora, D. M.; Reynisson, J.; Leung, I. K. H.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamides Bridges. Appl. Sci. 2019, 9, 2767. DOI: 10.3390/app9132767

50
Correddu, D.; Montaño López, J. d. J.; Vadakkedath, P. G.; Lai, A.; Pernes, J. I.; Watson, P. R.; Leung, I. K. H. An Improved Method for the Heterologous Production of Soluble Human Ribosomal Proteins in Escherichia coli. Sci. Rep. 2019, 9, 8884. DOI: 10.1038/s41598-019-45323-8

49
Correddu, D.; Leung, I. K. H. Targeting mRNA Translation in Parkinson’s Disease. Drug Discov. Today 2019, 24, 1295–1303. DOI: 10.1016/j.drudis.2019.04.003

48
Mozhaitsev, E. S.; Zakharenko, A. L.; Suslov, E. V.; Korchagina, D. V.; Zakharova, O. D.; Vasil’eva, I. A.; Chepanova, A. A.; Black, E.; Patel, J.; Chand, R.; Reynisson, J.; Leung, I. K. H.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments. Anti-Cancer Agents Med. Chem. 2019, 19, 463–472. DOI: 10.2174/1871520619666181207094243

47
Zakharenko, A. L.; Luzina, O. A.; Sokolov, D. N.; Kaledin, V. I.; Nikolin, V. P.; Popova, N. A.; Patel, J.; Zakharova, O. D.; Chepanova, A. A.; Zafar, A.; Reynisson, J.; Leung, E.; Leung, I. K. H.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. Novel Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Enhance the Therapeutic Impact of Topoteсan on In Vivo Tumor Models. Eur. J. Med. Chem. 2019, 161, 581–593. DOI: 10.1016/j.ejmech.2018.10.055

46
Son, S. J.; Huang, R.; Squire, C. J.; Leung, I. K. H. MCR-1: A Promising Target for Structure-Based Design of Inhibitors to Tackle Polymyxin Resistance. Drug Discov. Today 2019, 24, 206–216. DOI: 10.1016/j.drudis.2018.07.004

45
Abboud, M. I.; Chowdhury, R.; Leung, I. K. H.; Lippl, K.; Loenarz, C.; Claridge, T. D. W.; Schofield, C. J. Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain. ChemBioChem 2018, 19, 2262–2267. DOI: 10.1002/cbic.201800246

44
Li-Zhulanov, N. S.; Zakharenko, A. L.; Chepanova, A. A.; Patel, J.; Zafar, A.; Volcho, K. P.; Salakhutdinov, N. F.; Reynisson, J.; Leung, I. K. H.; Lavrik, O. I. A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold. Molecules 2018, 23, 2468. DOI: 10.3390/molecules23102468

43
Zhang, S.; De Leon Rodriguez, L. M.; Huang, R.; Leung, I. K. H.; Harris, P. W. R.; Brimble, M. A. Total Synthesis of the Proposed Structure of Talarolide A. Org. Biomol. Chem. 2018, 16, 5286–5293. DOI: 10.1039/C8OB01230J

42
McAllister, T. E.; Yeh, T.-L.; Abboud, M. I.; Leung, I. K. H.; Hookway, E. S.; King, O. N. F.; Bhushan, B.; Williams, S. T.; Hopkinson, R. J.; Muenzel, M.; Loik, N. D.; Chowdhury, R.; Oppermann, U.; Claridge, T. D. W.; Goto, Y.; Suga, H.; Schofield, C. J.; Kawamura, A. Non-Competitive Cyclic Peptides for Targeting Enzyme-Substrate Complexes. Chem. Sci. 2018, 9, 4569–4578. DOI: 10.1039/C8SC00286J

41
Abboud, M. I.; McAllister, T. E.; Leung, I. K. H.; Chowdhury, R.; Jorgensen, C.; Domene, C.; Mecinović, J.; Lippl, K.; Hancock, R. L.; Hopkinson, R. J.; Kawamura, A.; Claridge, T. D. W.; Schofield, C. J. 2-Oxoglutarate Regulates Binding of Hydroxylated Hypoxia-Inducible Factor to Prolyl Hydroxylase Domain 2. Chem. Commun. 2018, 54, 3130–3133. DOI: 10.1039/c8cc00387d

40
Zhang, S.; De Leon Rodriguez, L. M.; Leung, I. K. H.; Cook, G. M.; Harris, P. W.; Brimble, M. A. Total Synthesis and Conformational Study of Callyaerin A: Anti-Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z)-2,3-Diaminoacrylamide Moiety. Angew. Chem. Int. Ed. 2018, 57, 3631–3635. DOI: 10.1002/anie.201712792

39
Mbenza, N. M.; Vadakkedath, P. G.; McGillivray, D. J.; Leung, I. K. H. NMR Studies of the Non-Haem Fe(II) and 2-Oxoglutarate-Dependent Oxygenases. J. Inorg. Biochem. 2017, 177, 384–394. DOI: 10.1016/j.jinorgbio.2017.08.032

38
Li, Y.; Zafar, A.; Kilmartin, P. A.; Reynisson, J.; Leung, I. K. H. Development and Application of an NMR-Based Assay for Polyphenol Oxidases. ChemistrySelect 2017, 2, 10435–10441. DOI: 10.1002/slct.201702144

37
Bhusal, R. P.; Patel, K.; Kwai, B. X. C.; Swartjes, A.; Bashiri, G.; Reynisson, J.; Sperry, J.; Leung, I. K. H. Development of NMR and Thermal Shift Assays for the Evaluation of Mycobacterium tuberculosis Isocitrate Lyase Inhibitors. Med. Chem. Commun. 2017, 8, 2155–2163. DOI: 10.1039/C7MD00456G

36
Yeh, T.-L.; Leissing, T. M.; Abboud, M. I.; Thinnes, C. C.; Atasoylu, O.; Holt-Martyn, J. P.; Zhang, D.; Tumber, A.; Lippl, K.; Lohans, C. T.; Leung, I. K. H.; Morcrette, H.; Clifton, I. J.; Claridge, T. D. W.; Kawamura, A.; Flashman, E.; Lu, X.; Ratcliffe, P. J.; Chowdhury, R.; Pugh, C. W.; Schofield, C. J. Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase Inhibitors in Clinical Trials. Chem. Sci. 2017, 8, 7651–7668. DOI: 10.1039/C7SC02103H

35
Bhusal, R. P.; Bashiri, G.; Kwai, B. X. C.; Sperry, J.; Leung, I. K. H. Targeting Isocitrate Lyase for the Treatment of Latent Tuberculosis. Drug Discov. Today 2017, 22, 1008–1016. DOI: 10.1016/j.drudis.2017.04.012

34
Santoso, B.; Yanaranop, P.; Kang, H.; Leung, I. K. H.; Jin, J. A Critical Update on the Synthesis of Carboxylated Polymers of Intrinsic Microporosity (C-PIMs). Macromolecules 2017, 50, 3043–3050. DOI: 10.1021/acs.macromol.7b00344

33
Kong, C. H. Z.; Leung, I. K. H.; Sarojini, V. Synthetic Insect Antifreeze Peptides Modify Ice Crystal Growth Habit. CrystEngComm 2017, 19, 2163–2167. DOI: 10.1039/C7CE00232G

32
Huang, R.; Bonnichon, A.; Claridge, T. D. W.; Leung, I. K. H. Protein-Ligand Binding Affinity Determination by the WaterLOGSY Method: An Optimised Approach Considering Ligand Rebinding. Sci. Rep. 2017, 7, 43727. DOI: 10.1038/srep43727

31
Hanauer, T.; Hopkinson, R. J.; Patel, K.; Li, Y.; Correddu, D.; Kawamura, A.; Sarojini, V.; Leung, I. K. H.; Gruber, T. Selective Recognition of the Di/Trimethylammonium Motif by an Artificial Carboxycalixarene Receptor. Org. Biomol. Chem. 2017, 15, 1100–1105. DOI: 10.1039/C6OB02616H

30
Harris, P. W. R.; Cook, G. M.; Leung, I. K. H.; Brimble, M. A. An Efficient Chemical Synthesis of Lassomycin Enabled by an On-Resin Lactamisation/Off-Resin Methanolysis Strategy and Preparation of Chemical Variants. Aust. J. Chem. 2017, 70, 172–183. DOI: 10.1071/CH16499

29
Young, P. G.; Yosaatmadja, Y.; Harris, P. W. R.; Leung, I. K. H.; Baker, E. N.; Squire, C. J. Harnessing Ester Bond Chemistry for Protein Ligation. Chem. Commun. 2017, 53, 1502–1505. DOI: 10.1039/C6CC09899A

28
Huang, R.; Ayine-Tora, D. M.; Muhammad Rosdi, M. N.; Li, Y.; Reynisson, J.; Leung, I. K. H. Virtual Screening and Biophysical Studies Lead to HSP90 Inhibitors. Bioorg. Med. Chem. Lett. 2017, 27, 277–281. DOI: 10.1016/j.bmcl.2016.11.059

27
Zhang, S.; De Leon Rodriguez, L. M.; Lacey, E.; Piggott, A. M.; Leung, I. K. H.; Brimble, M. A. Cyclisation of Linear Tetrapeptides Containing N-Methylated Amino Acids Using 2-Propanephosphonic Acid Anhydride. Eur. J. Org. Chem. 2017, 2017, 149–158. DOI: 10.1002/ejoc.201601016

26
Lindsay, A. C.; Leung, I. K. H.; Sperry, J. Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction. Org. Lett. 2016, 18, 5404–5407. DOI: 10.1021/acs.orglett.6b02798

25
Chowdhury, R.; Leung, I. K. H.; Tian, Y.-M.; Abboud, M. I.; Ge, W.; Domene, C.; Cantrelle, F.-X.; Landrieu, I.; Hardy, A. P.; Pugh, C. W.; Ratcliffe, P. J.; Claridge, T. D. W.; Schofield, C. J. Structural Basis for Oxygen Degradation Domain Selectivity of the HIF Prolyl Hydroxylases. Nat. Commun. 2016, 7, 12673. DOI: 10.1038/ncomms12673

24
Huang, R.; Leung, I. K. H. Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery. Molecules 2016, 21, 910. DOI: 10.3390/molecules21070910

23
Khan, A.; Leśniak, R. K.; Brem, J.; Rydzik, A. M.; Choi, H.; Leung, I. K. H.; McDonough, M. A.; Schofield, C. J.; Claridge, T. D. W. Development and Application of Ligand-Based NMR Screening Assays for γ-Butyrobetaine Hydroxylase. Med. Chem. Commun. 2016, 7, 873–880. DOI: 10.1039/C6MD00004E

22
Hopkinson, R. J.; Leung, I. K. H.; Smart, T. J.; Rose, N. R.; Henry, L.; Claridge, T. D. W.; Schofield, C. J. Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans. PLoS ONE 2015, 10, e0145085. DOI: 10.1371/journal.pone.0145085

21
Chan, M. C.; Atasoylu, O.; Hodson, E.; Tumber, A.; Leung, I. K. H.; Chowdhury, R.; Gómez-Pérez, V.; Demetriades, M.; Rydzik, A. M.; Holt-Martyn, J.; Tian, Y.-M.; Bishop, T.; Claridge, T. D. W.; Kawamura, A.; Pugh, C. W.; Ratcliffe, P. J.; Schofield, C. J. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases With Activity in the Murine Brain. PLoS ONE 2015, 10, e0132004. DOI: 10.1371/journal.pone.0132004

20
Tarhonskaya, H.; Chowdhury, R.; Leung, I. K. H.; Loik, N. D.; McCullagh, J. S. O.; Claridge, T. D. W.; Schofield, C. J.; Flashman, E. Investigating the Contribution of the Active Site Environment to the Slow Reaction of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 With Oxygen. Biochem. J. 2014, 463, 363–372. DOI: 10.1042/BJ20140779

19
Rydzik, A. M.; Leung, I. K. H.; Kochan, G. T.; McDonough, M. A.; Claridge, T. D. W.; Schofield, C. J. Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-Piperidine-4-Carboxylic Acids. Angew. Chem. Int. Ed. 2014, 53, 10925–10927. DOI: 10.1002/anie.201406125

18
Scotti, J. S.; Leung, I. K. H.; Ge, W.; Bentley, M. A.; Paps, J.; Kramer, H. B.; Lee, J.; Aik, W.; Choi, H.; Paulsen, S. M.; Bowman, L. A. H.; Loik, N. D.; Horita, S.; Ho, C.-h.; Kershaw, N. J.; Tang, C. M.; Claridge, T. D. W.; Preston, G. M.; McDonough, M. A.; Schofield, C. J. Human Oxygen Sensing May Have Origins in Prokaryotic Elongation Factor Tu Prolyl-Hydroxylation. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 13331–13336. DOI: 10.1073/pnas.1409916111

17
Rydzik, A. M.; Leung, I. K. H.; Kochan, G. T.; Loik, N. D.; Henry, L.; McDonough, M. A.; Claridge, T. D. W.; Schofield, C. J. Comparison of the Substrate Selectivity and Biochemical Properties of Human and Bacterial γ-Butyrobetaine Hydroxylase. Org. Biomol. Chem. 2014, 12, 6354–6358. DOI: 10.1039/C4OB01167H

16
Tarhonskaya, H.; Szöllössi, A.; Leung, I. K. H.; Bush, J. T.; Henry, L.; Chowdhury, R.; Iqbal, A.; Claridge, T. D. W.; Schofield, C. J.; Flashman, E. Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases. Biochemistry 2014, 53, 2483–2493. DOI: 10.1021/bi500086p

15
Lingard, H.; Han, J. T.; Thompson, A. L.; Leung, I. K. H.; Scott, R. T. W.; Thompson, S.; Hamilton, A. D. Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation. Angew. Chem. Int. Ed. 2014, 53, 3650–3653. DOI: 10.1002/anie.201309353

14
Tarhonskaya, H.; Rydzik, A. M.; Leung, I. K. H.; Loik, N. D.; Chan, M. C.; Kawamura, A.; McCullagh, J. S. O.; Claridge, T. D. W.; Flashman, E.; Schofield, C. J. Non-Enzymatic Chemistry Enables 2-Hydroxyglutarate-Mediated Activation of 2-Oxoglutarate Oxygenases. Nat. Commun. 2014, 5, 3423. DOI: 10.1038/ncomms4423

13
Rydzik, A. M.; Leung, I. K. H.; Thalhammer, A.; Kochan, G. T.; Claridge, T. D. W.; Schofield, C. J. Fluoromethylated Derivatives of Carnitine Biosynthesis Intermediates – Synthesis and Applications. Chem. Commun. 2014, 50, 1175−1177. DOI: 10.1039/C3CC47581F

12
Bush, J. T.; Walport, L. J.; McGouran, J. F.; Leung, I. K. H.; Berridge, G.; van Berkel, S. S.; Basak, A.; Kessler, B. M.; Schofield, C. J. The Ugi Four-Component Reaction Enables Expedient Synthesis and Comparison of Photoaffinity Probes. Chem. Sci. 2013, 4, 4115−4120. DOI: 10.1039/C3SC51708J

11
van Berkel, S. S.; Nettleship, J. E.; Leung, I. K. H.; Brem, J.; Choi, H.; Stuart, D. I.; Claridge, T. D. W.; McDonough, M. A.; Owens, R. J.; Ren, J.; Schofield, C. J. Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. ACS Chem. Biol. 2013, 8, 2112–2116. DOI: 10.1021/cb400200h

10
Leung, I. K. H.; Demetriades, M.; Hardy, A. P.; Lejeune, C.; Smart, T. J.; Szöllössi, A.; Kawamura, A.; Schofield, C. J.; Claridge, T. D. W. Reporter Ligand NMR Screening Method for 2-Oxoglutarate Oxygenase Inhibitors. J. Med. Chem. 2013, 56, 547–555. DOI: 10.1021/jm301583m

9
Henry, L.; Leung, I. K. H.; Claridge, T. D. W.; Schofield, C. J. γ-Butyrobetaine Hydroxylase Catalyses a Stevens Type Rearrangement. Bioorg. Med. Chem. Lett. 2012, 22, 4975–4978. DOI: 10.1016/j.bmcl.2012.06.024

8
Rose, N. R.; Woon, E. C.; Tumber, A.; Walport, L. J.; Chowdhury, R.; Li, X. S.; King, O. N. F.; Lejeune, C.; Ng, S. S.; Krojer, T.; Chan, M. C.; Rydzik, A. M.; Hopkinson, R. J.; Che, K. H.; Daniel, M.; Strain-Damerell, C.; Gileadi, C.; Kochan, G.; Leung, I. K. H.; Dunford, J.; Yeoh, K. K.; Ratcliffe, P. J.; Burgess-Brown, N.; von Delft, F.; Muller, S.; Marsden, B.; Brennan, P. E.; McDonough, M. A.; Oppermann, U.; Klose, R. J.; Schofield, C. J.; Kawamura, A. The Plant Growth Regulator Daminozide Is a Selective Inhibitor of the Human KDM2/7 Histone Demethylases. J. Med. Chem. 2012, 55, 6639–6643. DOI: 10.1021/jm300677j

7
Rydzik, A. M.; Leung, I. K. H.; Kochan, G. T.; Thalhammer, A.; Oppermann, U.; Claridge, T. D. W.; Schofield, C. J. Development and Application of a Fluoride-Detection-Based Fluorescence Assay for γ-Butyrobetaine Hydroxylase. ChemBioChem 2012, 13, 1559–1563. DOI: 10.1002/cbic.201200256

6
Demetriades, M.; Leung, I. K. H.; Chowdhury, R.; Chan, M. C.; McDonough, M. A.; Yeoh, K. K.; Tian, Y.-M.; Claridge, T. D. W.; Ratcliffe, P. J.; Woon, E. C. Y.; Schofield, C. J. Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors. Angew. Chem. Int. Ed. 2012, 51, 6672–6675. DOI: 10.1002/anie.201202000

5
Rotili, D.; Altun, M.; Kawamura, A.; Wolf, A.; Fischer, R.; Leung, I. K. H.; Mackeen, M. M.; Tian, Y.-M.; Ratcliffe, P. J.; Mai, A.; Kessler, B. M.; Schofield, C. J. A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases. Chem. Biol. 2011, 18, 642–654. DOI: 10.1016/j.chembiol.2011.03.007

4
Leung, I. K. H.; Brown Jr, T.; Schofield, C. J.; Claridge, T. D. W. An Approach to Enzyme Inhibition Employing Reversible Boronate Ester Formation. Med. Chem. Commun. 2011, 2, 390–395. DOI: 10.1039/C1MD00011J

3
Chowdhury, R.; Yeoh, K. K.; Tian, Y.-M.; Hillringhaus, L.; Bagg, E. A.; Rose, N. R.; Leung, I. K. H.; Li, X. S.; Woon, E. C. Y.; Yang, M.; McDonough, M. A.; King, O. N.; Clifton, I. J.; Klose, R. J.; Claridge, T. D. W.; Ratcliffe, P. J.; Schofield, C. J. ; Kawamura, A. The Oncometabolite 2-Hydroxyglutarate Inhibits Histone Lysine Demethylases. EMBO Rep. 2011, 12, 463–469. DOI: 10.1038/embor.2011.43

2
Leung, I. K. H.; Krojer, T. J.; Kochan, G. T.; Henry, L.; von Delft, F.; Claridge, T. D. W.; Oppermann, U.; McDonough, M. A.; Schofield, C. J. Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase. Chem. Biol. 2010, 17, 1316–1324. DOI: 10.1016/j.chembiol.2010.09.016

1
Leung, I. K. H.; Flashman, E.; Yeoh, K. K.; Schofield, C. J.; Claridge, T. D. W. Using NMR Solvent Water Relaxation to Investigate Metalloenzyme–Ligand Binding Interactions. J. Med. Chem. 2010, 53, 867–875. DOI: 10.1021/jm901537q

Book Chapters

5
Bonnet, O.; Fa’aui, T.; Leung, I. K. H.; Yi, S.; Zhuang, W.-Q. Challenges and Applications of Laccase in Bioremediation. In Laccase and Polyphenol Oxidase. Biochemistry and Biotechnological Applications; Leung, I. K. H., Ed.; Foundations and Frontiers in Enzymology; Academic Press: London; San Diego, MA; Cambridge, MA, 2025; Chapter 7, pp 153–185.DOI: 10.1016/B978-0-443-13301-5.00007-X

4
Le Viet, L. H.; Matsuda, T.; Leung, I. K. H. Laccases: Biological Functions and Potential Applications. In Laccase and Polyphenol Oxidase. Biochemistry and Biotechnological Applications; Leung, I. K. H., Ed.; Foundations and Frontiers in Enzymology; Academic Press: London; San Diego, MA; Cambridge, MA, 2025; Chapter 6, pp 133–152. DOI: 10.1016/B978-0-443-13301-5.00006-8

3
Chan, Y. Y.; Mbenza, N. M.; Chan, M. C.; Leung, I. K. H. Assays to Study Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (PHD2), a Key Human Oxygen Sensing Protein. In Oxygen Sensing, Methods and Protocol; Weinert, E. E., Ed.; Methods in Molecular Biology; Humana: New York, NY, 2023; Vol. 2648, Chapter 12, pp 187–206. DOI: 10.1007/978-1-0716-3080-8_12

2
Huang, R.; Leung, I. K. H. Protein–Small Molecule Interactions by WaterLOGSY. In Biological NMR Part B; Wand, A. J., Ed.; Methods in Enzymology; Academic Press: Cambridge, MA, 2019; Vol. 615, Chapter 14, pp 477–500. DOI: 10.1016/bs.mie.2018.08.020

1
Xiang, L.-W.; Melton, L. D.; Leung, I. K. H. Interactions of β-Lactoglobulin With Small Molecules. In Encyclopedia of Food Chemistry; Melton, L., Shahidi, F., Varelis, P., Eds.; Elsevier: Amsterdam, 2019; Vol. 2, pp 560–565. DOI: 10.1016/B978-0-08-100596-5.21488-1

Edited Books

1
Laccase and Polyphenol Oxidase. Biochemistry and Biotechnological Applications; Leung, I. K. H., Ed.; Foundations and Frontiers in Enzymology; Academic Press: London; San Diego, MA; Cambridge, MA, 2025. DOI: 10.1016/C2022-0-01789-X